The use of platelet concentrates has had a long-history of use in various fields of medicine as an autologous source of growth factors fabricated utilizing whole blood. While platelet rich plasma (PRP) was proposed as a first-generation platelet concentrate over 3 decades ago, over the past 10 years, platelet rich fibrin (PRF) has seen a steady increase in utilization for a variety of medical procedures due to its lack of anti-coagulation factors favoring fibrin clot formation and faster wound healing. More recently, the development of a liquid PRF provides a new formulation of liquid PRF without using anti-coagulation factors that may specifically be combined with currently available bone biomaterials favoring particle stability, angiogenesis and tissue integration. This talk aims to highlight the recent advancements made with respect to the newest formulations of platelet concentrates including recent developments in horizontal centrifugation and liquid concentrated-PRF (C-PRF) to further speed wound healing and tissue regeneration for various clinical indications faced in routine daily dental practice. Furthermore, protocols to extended the working properties of PRF from 2-3 weeks to 4-6 months are discussed (e=PRF) including their current clinical applications.